Can Designer Indels Be Tailored by Gene Editing?
نویسندگان
چکیده
منابع مشابه
Frameshift indels introduced by genome editing can lead to in-frame exon skipping
The introduction of frameshift indels by genome editing has emerged as a powerful technique to study the functions of uncharacterized genes in cell lines and model organisms. Such mutations should lead to mRNA degradation owing to nonsense-mediated mRNA decay or the production of severely truncated proteins. Here, we show that frameshift indels engineered by genome editing can also lead to skip...
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ژورنال
عنوان ژورنال: BioEssays
سال: 2019
ISSN: 0265-9247,1521-1878
DOI: 10.1002/bies.201900126